Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Fish Oil Concentrate
1.3 g (1,300 mg)
†
Docosahexaenoic Acid (DHA)
1 g (1,000 mg)
†
Top Medical Research Studies
2
We explored the effects of omega-3 fatty acids, specifically EPA and DHA, on heart failure markers in patients who had suffered a heart attack. In a large study involving nearly 4,837 participants aged 60-80, we administered various types of margarine for 40 months, some enriched with these fatty acids.
However, our results indicated that there was no significant change in NT-proBNP levels, a crucial heart failure biomarker, among those taking the supplements compared to a placebo group. Thus, it appears that modest EPA and DHA supplementation does not significantly affect heart failure risks after a myocardial infarction.
However, our results indicated that there was no significant change in NT-proBNP levels, a crucial heart failure biomarker, among those taking the supplements compared to a placebo group. Thus, it appears that modest EPA and DHA supplementation does not significantly affect heart failure risks after a myocardial infarction.
9.5
We aimed to understand the role of docosahexaenoic acid (DHA) in improving heart function after a heart attack. Using both laboratory and animal models, we discovered that DHA helps cardiomyocytes survive oxygen deprivation and limits damage post-heart attack.
DHA reduced heart tissue injury and improved overall heart function. Our results showed that it promotes a protective process known as autophagy, which is linked to the AMPK/mTOR signaling pathway. This study highlights the potential of DHA in supporting heart health after a myocardial infarction.
DHA reduced heart tissue injury and improved overall heart function. Our results showed that it promotes a protective process known as autophagy, which is linked to the AMPK/mTOR signaling pathway. This study highlights the potential of DHA in supporting heart health after a myocardial infarction.
9
Omega-3s reduce heart attack damage
We explored how two omega-3 fatty acids, EPA and DHA, affect heart attack damage by testing them in adult male rats over 14 days. After subjecting these animals to a heart injury, we measured the damage.
Our findings revealed that both EPA and DHA effectively reduced heart attack size when tested alone, while their combination didn’t show any added benefit. Notably, DHA also decreased specific cellular activities related to damage, making it a standout in promoting heart health in our model.
Our findings revealed that both EPA and DHA effectively reduced heart attack size when tested alone, while their combination didn’t show any added benefit. Notably, DHA also decreased specific cellular activities related to damage, making it a standout in promoting heart health in our model.
Most Useful Reviews
8.8
Energises heart health
Good old fish oil! I have used this product for many years, and it has always been beneficial. It's especially helpful for health when combined with Coenzyme Q10, as the heart seems to receive an energy boost. Gelatin is also beneficial for skin, hair, and nails.
8.8
Promotes heart health
Good quality, beneficial for health. Omega three fish oil has no cholesterol and is excellent for heart inflammation.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.4
- All Researches
9.5
We aimed to understand the role of docosahexaenoic acid (DHA) in improving heart function after a heart attack. Using both laboratory and animal models, we discovered that DHA helps cardiomyocytes survive oxygen deprivation and limits damage post-heart attack.
DHA reduced heart tissue injury and improved overall heart function. Our results showed that it promotes a protective process known as autophagy, which is linked to the AMPK/mTOR signaling pathway. This study highlights the potential of DHA in supporting heart health after a myocardial infarction.
DHA reduced heart tissue injury and improved overall heart function. Our results showed that it promotes a protective process known as autophagy, which is linked to the AMPK/mTOR signaling pathway. This study highlights the potential of DHA in supporting heart health after a myocardial infarction.
9
DHA and EPA aid heart recovery
We investigated how eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) influence heart function after a heart attack in rats. Our study showed both EPA and DHA improved heart health by reducing heart cell enlargement and preventing worsening heart failure. We found that they effectively inhibited certain cellular activities linked to heart muscle damage. Rats receiving these treatments maintained better heart function and showed less structural damage over six weeks. Ultimately, both EPA and DHA offered similar protective benefits after heart attacks.
9
We examined how an intravenous bolus of Omega-3, specifically a ratio of EPA to DHA at 6:1, affects heart function during myocardial ischemia-reperfusion in a rat model. Administering this Omega-3 before the reperfusion showed significant improvements in blood pressure and blood flow, while reducing markers of heart damage and inflammation. These findings suggest that while it's effective in rats, further research is necessary to see how it might work in human heart attack scenarios.
9
Omega-3s reduce heart attack damage
We explored how two omega-3 fatty acids, EPA and DHA, affect heart attack damage by testing them in adult male rats over 14 days. After subjecting these animals to a heart injury, we measured the damage.
Our findings revealed that both EPA and DHA effectively reduced heart attack size when tested alone, while their combination didn’t show any added benefit. Notably, DHA also decreased specific cellular activities related to damage, making it a standout in promoting heart health in our model.
Our findings revealed that both EPA and DHA effectively reduced heart attack size when tested alone, while their combination didn’t show any added benefit. Notably, DHA also decreased specific cellular activities related to damage, making it a standout in promoting heart health in our model.
9
DHA aids post-heart attack recovery
We explored the effects of docosahexaenoic acid (DHA) on heart attack recovery in rats. The study aimed to understand how DHA, alongside eicosapentaenoic acid (EPA), can influence heart failure following myocardial infarction (MI).
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Energises heart health
Good old fish oil! I have used this product for many years, and it has always been beneficial. It's especially helpful for health when combined with Coenzyme Q10, as the heart seems to receive an energy boost. Gelatin is also beneficial for skin, hair, and nails.
8.8
Promotes heart health
Good quality, beneficial for health. Omega three fish oil has no cholesterol and is excellent for heart inflammation.
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Chiusolo S, Bork CS, Gentile F, Lundbye-Christensen S, Harris WS, et al. Adipose tissue n-3/n-6 fatty acids ratios versus n-3 fatty acids fractions as predictors of myocardial infarction. Am Heart J. 2023;262:38. doi:10.1016/j.ahj.2023.03.019
- Yokoyama Y, Kuno T, Morita SX, Slipczuk L, Takagi H, et al. Eicosapentaenoic Acid for Cardiovascular Events Reduction- Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. J Cardiol. 2022;80:416. doi:10.1016/j.jjcc.2022.07.008
- Sunagawa Y, Katayama A, Funamoto M, Shimizu K, Shimizu S, et al. The polyunsaturated fatty acids, EPA and DHA, ameliorate myocardial infarction-induced heart failure by inhibiting p300-HAT activity in rats. J Nutr Biochem. 2022;106:109031. doi:10.1016/j.jnutbio.2022.109031
- Halade GV, Kain V, De La Rosa X, Lindsey ML. Metabolic transformation of fat in obesity determines the inflammation resolving capacity of splenocardiac and cardiorenal networks in heart failure. Am J Physiol Heart Circ Physiol. 2022;322:H953. doi:10.1152/ajpheart.00684.2021
- Shi Y, Li H, Wu T, Wang Q, Zhu Q, et al. Docosahexaenoic Acid-Enhanced Autophagic Flux Improves Cardiac Dysfunction after Myocardial Infarction by Targeting the AMPK/mTOR Signaling Pathway. Oxid Med Cell Longev. 2022;2022:1509421. doi:10.1155/2022/1509421
- Wang CP, Lee CC, Wu DY, Chen SY, Lee TM. Differential effects of EPA and DHA on PPARγ-mediated sympathetic innervation in infarcted rat hearts by GPR120-dependent and -independent mechanisms. J Nutr Biochem. 2022;103:108950. doi:10.1016/j.jnutbio.2022.108950
- Myhre PL, Kalstad AA, Tveit SH, Laake K, Schmidt EB, et al. Changes in eicosapentaenoic acid and docosahexaenoic acid and risk of cardiovascular events and atrial fibrillation: A secondary analysis of the OMEMI trial. J Intern Med. 2022;291:637. doi:10.1111/joim.13442
- Pertiwi K, Küpers LK, de Goede J, Zock PL, Kromhout D, et al. Dietary and Circulating Long-Chain Omega-3 Polyunsaturated Fatty Acids and Mortality Risk After Myocardial Infarction: A Long-Term Follow-Up of the Alpha Omega Cohort. J Am Heart Assoc. 2021;10:e022617. doi:10.1161/JAHA.121.022617
- Habicht I, Mohsen G, Eichhorn L, Frede S, Weisheit C, et al. DHA Supplementation Attenuates MI-Induced LV Matrix Remodeling and Dysfunction in Mice. Oxid Med Cell Longev. 2020;2020:7606938. doi:10.1155/2020/7606938
- Roy J, Fauconnier J, Oger C, Farah C, Angebault-Prouteau C, et al. Non-enzymatic oxidized metabolite of DHA, 4(RS)-4-F-neuroprostane protects the heart against reperfusion injury. Free Radic Biol Med. 2017;102:229. doi:10.1016/j.freeradbiomed.2016.12.005
- Burban M, Meyer G, Olland A, Séverac F, Yver B, et al. An Intravenous Bolus of Epa: Dha 6: 1 Protects Against Myocardial Ischemia-Reperfusion-Induced Shock. Shock. 2016;46:549.
- Madingou N, Gilbert K, Tomaro L, Prud'homme Touchette C, Trudeau F, et al. Comparison of the effects of EPA and DHA alone or in combination in a murine model of myocardial infarction. Prostaglandins Leukot Essent Fatty Acids. 2016;111:11. doi:10.1016/j.plefa.2016.06.001
- Hu XF, Laird BD, Chan HM. Mercury diminishes the cardiovascular protective effect of omega-3 polyunsaturated fatty acids in the modern diet of Inuit in Canada. Environ Res. 2017;152:470. doi:10.1016/j.envres.2016.06.001
- Arakawa K, Himeno H, Kirigaya J, Otomo F, Matsushita K, et al. Impact of n-3 polyunsaturated fatty acids in predicting ischemia/reperfusion injury and progression of myocardial damage after reperfusion in patients with ST-segment elevation acute myocardial infarction. J Cardiol. 2015;66:101. doi:10.1016/j.jjcc.2015.03.009
- Bergkvist C, Berglund M, Glynn A, Wolk A, Åkesson A. Dietary exposure to polychlorinated biphenyls and risk of myocardial infarction - a population-based prospective cohort study. Int J Cardiol. 2015;183:242. doi:10.1016/j.ijcard.2015.01.055
- Hoogeveen EK, Geleijnse JM, Kromhout D, van't Sant P, Gemen EF, et al. No effect of n-3 fatty acids supplementation on NT-proBNP after myocardial infarction: the Alpha Omega Trial. Eur J Prev Cardiol. 2015;22:648. doi:10.1177/2047487314536694
- Hamaya R, Cook NR, Sesso HD, Buring JE, Manson JE. A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events. Am J Clin Nutr. 2025. doi:10.1016/j.ajcnut.2025.02.028
- Dinu M, Sofi F, Lotti S, Colombini B, Mattioli AV, et al. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis. Eur J Prev Cardiol. 2024;31:1863. doi:10.1093/eurjpc/zwae184
- Le VT, Knight S, Watrous JD, Najhawan M, Dao K, et al. Higher docosahexaenoic acid levels lower the protective impact of eicosapentaenoic acid on long-term major cardiovascular events. Front Cardiovasc Med. 2023;10:1229130. doi:10.3389/fcvm.2023.1229130
- Luo X, Liu M, Wang S, Chen Y, Bao X, et al. Combining metabolomics and OCT to reveal plasma metabolic profiling and biomarkers of plaque erosion and plaque rupture in STEMI patients. Int J Cardiol. 2023;390:131223. doi:10.1016/j.ijcard.2023.131223
- Myhre PL, Berge T, Kalstad AA, Tveit SH, Laake K, et al. Omega-3 fatty acid supplements and risk of atrial fibrillation and 'micro-atrial fibrillation': A secondary analysis from the OMEMI trial. Clin Nutr. 2023;42:1657. doi:10.1016/j.clnu.2023.07.002
- Chiusolo S, Bork CS, Gentile F, Lundbye-Christensen S, Harris WS, et al. Adipose tissue n-3/n-6 fatty acids ratios versus n-3 fatty acids fractions as predictors of myocardial infarction. Am Heart J. 2023;262:38. doi:10.1016/j.ahj.2023.03.019
- Bork CS, Lundbye-Christensen S, Venø SK, Lasota AN, Tjønneland A, et al. Intake of marine and plant-derived n-3 fatty acids and development of atherosclerotic cardiovascular disease in the Danish Diet, Cancer and Health cohort. Eur J Nutr. 2023;62:1389. doi:10.1007/s00394-022-03081-w
- Park GH, Cho JH, Lee D, Kim Y. Association between Seafood Intake and Cardiovascular Disease in South Korean Adults: A Community-Based Prospective Cohort Study. Nutrients. 2022;14. doi:10.3390/nu14224864
- Bassuk SS, Manson JE. Marine omega-3 fatty acid supplementation and prevention of cardiovascular disease: update on the randomized trial evidence. Cardiovasc Res. 2023;119:1297. doi:10.1093/cvr/cvac172
- Alfaddagh A, Kapoor K, Dardari ZA, Bhatt DL, Budoff MJ, et al. Omega-3 fatty acids, subclinical atherosclerosis, and cardiovascular events: Implications for primary prevention. Atherosclerosis. 2022;353:11. doi:10.1016/j.atherosclerosis.2022.06.1018
- Sunagawa Y, Katayama A, Funamoto M, Shimizu K, Shimizu S, et al. The polyunsaturated fatty acids, EPA and DHA, ameliorate myocardial infarction-induced heart failure by inhibiting p300-HAT activity in rats. J Nutr Biochem. 2022;106:109031. doi:10.1016/j.jnutbio.2022.109031
- Halade GV, Kain V, De La Rosa X, Lindsey ML. Metabolic transformation of fat in obesity determines the inflammation resolving capacity of splenocardiac and cardiorenal networks in heart failure. Am J Physiol Heart Circ Physiol. 2022;322:H953. doi:10.1152/ajpheart.00684.2021
- Shi Y, Li H, Wu T, Wang Q, Zhu Q, et al. Docosahexaenoic Acid-Enhanced Autophagic Flux Improves Cardiac Dysfunction after Myocardial Infarction by Targeting the AMPK/mTOR Signaling Pathway. Oxid Med Cell Longev. 2022;2022:1509421. doi:10.1155/2022/1509421
- Wang CP, Lee CC, Wu DY, Chen SY, Lee TM. Differential effects of EPA and DHA on PPARγ-mediated sympathetic innervation in infarcted rat hearts by GPR120-dependent and -independent mechanisms. J Nutr Biochem. 2022;103:108950. doi:10.1016/j.jnutbio.2022.108950
- Myhre PL, Kalstad AA, Tveit SH, Laake K, Schmidt EB, et al. Changes in eicosapentaenoic acid and docosahexaenoic acid and risk of cardiovascular events and atrial fibrillation: A secondary analysis of the OMEMI trial. J Intern Med. 2022;291:637. doi:10.1111/joim.13442
- Pertiwi K, Küpers LK, de Goede J, Zock PL, Kromhout D, et al. Dietary and Circulating Long-Chain Omega-3 Polyunsaturated Fatty Acids and Mortality Risk After Myocardial Infarction: A Long-Term Follow-Up of the Alpha Omega Cohort. J Am Heart Assoc. 2021;10:e022617. doi:10.1161/JAHA.121.022617
